谱璟科技多平台助力的代表性科研成果

发布时间：2022-05-26

l  蛋白质-蛋白质互作技术平台：

1. Batool A, Liu H, Liu Y-X, Chen S-R: CD83, a Novel MAPK Signaling Pathway Interactor, Determines Ovarian Cancer Cell Fate. Cancers 2020, 12(8):2269.

2.  Gao Y, Liu S, Guo Q, Zhang S, Zhao Y, Wang H, Li T, Gong Y, Wang Y, Zhang T et al: Increased expression of TRIP13 drives the tumorigenesis of bladder cancer in association with the EGFR signaling pathway. International Journal of Biological Sciences 2019, 15(7):1488-1499.

3.  Yu W, Tang L, Lin F, Yao Y, Shen Z: DGKZ Acts as a Potential Oncogene in Osteosarcoma Proliferation Through Its Possible Interaction With ERK1/2 and MYC Pathway. Frontiers in Oncology 2019, 8(655).

4. Zhang X, Gao D, Fang K, Guo Z, Li L: Med19 is targeted by miR-101–3p/miR-422a and promotes breast cancer progression by regulating the EGFR/MEK/ERK signaling pathway. Cancer Letters 2019, 444:105-115.

5. Sun Y, Bao Q, Xuan B, Xu W, Pan D, Li Q, Qian Z, Jung JU: Human Cytomegalovirus Protein pUL38 Prevents Premature Cell Death by Binding to Ubiquitin-Specific Protease 24 and Regulating Iron Metabolism. Journal of Virology 2018, 92(13):e00191-00118.

6. Sun T, Du W, Xiong H, Yu Y, Weng Y, Ren L, Zhao H, Wang Y, Chen Y, Xu J et al: TMEFF2 Deregulation Contributes to Gastric Carcinogenesis and Indicates Poor Survival Outcome. Clinical Cancer Research 2014, 20(17):4689-4704.

l  lncRNA-蛋白质互作技术平台：

1. Sun T-T, He J, Liang Q, Ren L-L, Yan T-T, Yu T-C, Tang J-Y, Bao Y-J, Hu Y, Lin Y et al: LncRNA GClnc1 Promotes Gastric Carcinogenesis and May Act as a Modular Scaffold of WDR5 and KAT2A Complexes to Specify the Histone Modification Pattern. Cancer Discovery 2016, 6(7):784-801.

2.  Tang J, Yan T, Bao Y, Shen C, Yu C, Zhu X, Tian X, Guo F, Liang Q, Liu Q et al: LncRNA GLCC1 promotes colorectal carcinogenesis and glucose metabolism by stabilizing c-Myc. Nature Communications 2019, 10(1):3499.

l  SM(小分子)-蛋白质互作技术平台：

1. Chen C, Gong L, Liu X, Zhu T, Zhou W, Kong L, Luo J: Identification of peroxiredoxin 6 as a direct target of withangulatin A by quantitative chemical proteomics in non-small cell lung cancer. Redox Biology 2021, 46:102130.

2.  Chen C, Liu X, Gong L, Zhu T, Zhou W, Kong L, Luo J: Identification of Tubocapsanolide A as a novel NLRP3 inhibitor for potential treatment of colitis. Biochemical Pharmacology 2021, 190:114645.

3. Chen C, Zhu T, Liu X, Zhu D, Zhang Y, Wu S, Han C, Zhang H, Luo J, Kong L: Identification of a novel PHGDH covalent inhibitor by chemical proteomics and phenotypic profiling. Acta Pharmaceutica Sinica B 2021.

4. Zhu D, Li S, Chen C, Wang S, Zhu J, Kong L, Luo J: Tubocapsenolide A targets C-terminal cysteine residues of HSP90 to exert the anti-tumor effect. Pharmacological Research 2021, 166:105523.

l  SILAC技术平台：

1. Cao T, Zhang L, Zhang Y, Yan G, Fang C, Bao H, Lu H: Site-Specific Quantification of Protein Ubiquitination on MS2 Fragment Ion Level via Isobaric Peptide Labeling. Analytical Chemistry 2017, 89(21):11468-11475.

2. Di Y, Zhang Y, Zhang L, Tao T, Lu H: MdFDIA: A Mass Defect Based Four-Plex Data-Independent Acquisition Strategy for Proteome Quantification. Analytical Chemistry 2017, 89(19):10248-10255.

l  分子与细胞技术平台：

1. Liu Z, Yang Y, Zhang Y, Ye X, Wang L, Xu G: Stomatin-like protein 2 is associated with the clinicopathological features of human papillary thyroid cancer and is regulated by TGF-β in thyroid cancer cells. Oncol Rep 2014, 31(1):153-160.

2. Lv X, Zhang L, Zhu Y, Said HM, Shi J, Xu G: Regulative Effect of Nampt on Tumor Progression and Cell Viability in Human Colorectal Cancer. Journal of Cancer 2015, 6(9):849-858.

3. Wang WY, Chen Y, Su X, Tang D, Ben QW, Yao WY, Chen P, Yuan YZ: Resistin-Like Molecule-α Causes Lung Injury in Rats with Acute Pancreatitis by Activating the PI-3K/Akt-NF-κB Pathway and Promoting Inflammatory Cytokine Release. Current Molecular Medicine 2016, 16(7):677-687.